Brisbane’s Gallery of Modern Art has opened their largest-ever exhibition by an Australian artist, showcasing genetically-modified human-pig hybrids.

Patricia Piccinini's Curious Affection exhibition opened in Brisbane on Saturday featuring fields of more than 3000 flower sculptures as well as 70 other sculptures, photographs, videos and drawings.

It is the first time in five years that the entire GOMA ground floor has been handed over to a single artist.

GOMA director, Chris Saines, said Ms Piccinini's extraordinary creatures had been unleashed as the project gets us thinking about the rapidly accelerating interactions and overlaps between human and non-human worlds.