Jaywalkers could soon face fines of up to $48 for crossing intersections in Brisbane's CBD while the red ‘don’t walk’ signal is illuminated.

The new awareness campaign comes after two pedestrians died and a further 40 seriously injured jaywalking in the CBD within the past 12 months.

Queensland Police revealed five high-risk intersections that they'll be targeting in coming months: Upper Roma St and the Northern Busway, Edward and Ann St, Adelaide and Creek St, Elizabeth and Albert St and Adelaide and Albert St.