Two people have died and three Australians, including two experienced Qantas pilots, have been injured in a plane crash in South Africa.

Video from the airport shows the 64-year-old plane, with 19 people on board, barely lift off the runway, with smoke pouring from one of its engines, crashing shortly after.

A South African technician on board was killed in the impact, and three people were injured on the ground, one later succumbing to their injuries.

The Australian pilots, both from Sydney, were seriously injured and taken to hospital.

In a statement, a Qantas spokesperson said the company had reached out to the men and was providing "whatever support we can".