A program to reintroduce eastern quolls to mainland Australia has achieved success with 15 babies found in the pouches of three adult females.

Twenty eastern quolls bred in a wildlife park in Tasmania were released into the Booderee National Park on the NSW South Coast in March.

At first there were serious concerns the repopulation program would not succeed as a number of the marsupials became roadkill, or fell prey to foxes.

But pouch checks on the remaining females revealed that three were carrying five babies each.

Director of Rewilding Australia, Rob Brewster said they were the first eastern quolls born in the wild on the Australian mainland in more than 50 years.