A 45-year-old man is in custody and is likely to be charged with the murder of a 21-year-old Gold Coast woman who died after falling from a balcony in Southport in 2013.

Police allege Titans cheerleader Breeana Robinson, who was legally blind, was thrown from an 11th-storey balcony.

Detective Inspector Brendan Smith of the Gold Coast District Criminal Investigation Branch said today's arrest was the culmination of years of hard work by detectives.