Two Queensland twins are making history for becoming the first pair of semi-identical twins in the world to be identified during pregnancy.

Twins of their kind do not usually survive as embryos, which makes the four-year-old siblings only the second set of known semi-identical twins in the world.

Queensland University of Technology clinical geneticist Michael Gabbett has done extensive tests on the twins, and said the pair, despite being a girl and a boy, could easily pass for identical in appearance.