Sigma Healthcare's chief executive Mark Hooper has told investors that the company takes its obligations to properly handle stock processed through its distribution centres "very seriously" and there were never any reports from its workers about the alleged mishandling of prescription drugs.

On Wednesday, investors delivered a significant vote against the company's remuneration report at its shareholder meeting with the company also facing questions over claims that the company may have failed to properly handle over-the-counter and prescription drugs that get processed through its distribution centres.

Worker claims include that prescription medicines used to treat bacterial infections, depression, high blood pressure and diabetes were left out in 30-to-40-degree heat for hours over the summer months at some sites.