The national shortage is expected to continue until May 2022.
Estradiol valerate, also known by the brand name Progynova, replaces the hormone estradiol in the body.
This hormone declines with menopause in women and is used in the treatment of gender dysphoria.
The shortage has come due to a manufacturing problem at the pharmaceutical company Bayer earlier this year.
If you are concerned about the impact this may have about you, consult your doctor for advice or a change of scripts.