Queensland experts are predicting hundreds of daily COVID cases once the southern border reopens.

The Queensland Premier is yet to put a date on the borders reopening, but infectious disease physician Paul Griffin has said that maintaining zero cases is not something we can sustain forever.

UQ Virologist Ian Mackay, has said that hitting 80 per cent vaccination will not stop an outbreak.

However, Mr Mackay expects high vaccination rates to curb hospitalisations and deaths.